- Prevention and treatment of scurvy.
- Symptoms of mild deficiency may include faulty bone and tooth development,gingivitis, bleeding gums, and loosened teeth. Febrile states, chronic illness, and infection (pneumonia, whooping cough, tuberculosis, diphtheria, sinusitis, rheumatic fever, etc.) increase the need for ascorbic acid.
Chống chỉ định:
- Known hypersensitivity to ascorbic acid or any ingredient in the formulation.
- Large dose of ascorbic acid should be avoid in patients with:
+ Glucose - 6 - phosphate dehydrogenase deficiency (risk of hemolytic anemia).
+ History of nephrolithiasis, hyperoxaluria (increased risk of renal stone formation).
+ Thalassemia (increased risk of iron absorption).
Tác dụng phụ:
- Ascorbic acid is usually nontoxic; however, nausea, vomiting, heartburn, abdominal cramps, fatigue, flushing, headache, insomnia, and sleepiness have been reported.
- GI disturbances are the most common adverse effects associated with high vitamin C intake (e.g., 3 g or more daily). Diarrhea may occur after oral dosage of 1 g daily or greater. Other GI disturbances associated with high vitamin C intake include nausea, abdominal cramps, transient colic, and flatulent distention.
- Ascorbic acid may cause acidification of the urine, precipitation of urate, cystine, or oxalate stones, or drugs in the urinary tract.
- About 5% of individuals have been reported to develop hyperoxaluria after large doses of ascorbic acid.
Vitamin C STADA® 1g is only administered orally. The effervescent tablet is dissolved in a glass of water.
Adults: 1 effervescent tablet daily.
Hạn sử dụng: 24 months from the date of manufacturing.
- Prolonged use of large doses of ascorbic acid may result in increased metabolism of the drug (“systemic conditioning”), scurvy may occur when intake of the vitamin is reduced to normal. Ingestion of large doses of the vitamin during pregnancy has resulted in scurvy in neonates.
- Hemolysis has been associated with ascorbic acid administration in neonates with glucose - 6 - phosphate dehydrogenase deficiency and in otherwise healthy premature neonates.